上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (1): 89-.doi: 10.3969/j.issn.1674-8115.2011.01.021

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基因多态性与胃癌化疗敏感性的研究进展

郑磊贞1, 王志杰2   

  1. 1.上海交通大学 |医学院附属新华医院肿瘤科, 上海 200092；2.第二军医大学附属长征医院肿瘤科, 上海 200003
  • 出版日期:2011-01-28 发布日期:2011-02-01
  • 作者简介:郑磊贞（1965—）, 女, 主任医师, 硕士生导师；电子信箱: zhengleizhen2006@126.com。
  • 基金资助:

    上海市卫生局基金（2008135）

Research progress of gene polymorphisms and chemosensitivity for gastric cancer

ZHENG Lei-zhen1, WANG Zhi-jie2   

  1. 1.Department of Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China；2.Department of Oncology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
  • Online:2011-01-28 Published:2011-02-01
  • Supported by:

    Shanghai Municipal Health Bureau Foundation, 2008135

PDF (PC)

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摘要：

药物化疗是胃癌抗肿瘤治疗的重要手段，氟尿嘧啶类和铂类药物是胃癌化疗的常规用药，但相同药物对不同患者往往产生不同的疗效，因此确定药物疗效的影响因素对于提高化疗效果至关重要。该文结合国内外化疗敏感性研究的最新进展，系统综述了氟尿嘧啶类和铂类等药物相关基因多态性与胃癌化疗敏感性研究的关系，以期为胃癌个体化治疗提供依据。

关键词: 胃癌, 化疗敏感性, 多态性

Abstract:

Chemotherapy plays an important role in the treatment of gastric cancer, with fluorouracil and platinum being the common drugs. However, patients respond differently to the same drugs, the mechanism of which may be important to be clarified to improve the efficacy of chemotherapy. This review systematically highlights the relationship between gene polymorphisms and chemosensitivity for gastric cancer according to the latest studies, which may provide evidences for the personalised treatment for gastric cancer.

Key words: gastric cancer, chemosensitivity, polymorphisms