上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (8): 1096-.doi: 10.3969/j.issn.1674-8115.2011.08.010

• 专题报道（眼科视觉科学） • 上一篇    下一篇

近视与眼及全身免疫炎症关系的回顾和展望

周激波1,2, 瞿 佳1   

  1. 1.卫生部视光学研究中心, 温州 325027； 2.上海交通大学 医学院附属第九人民医院眼科, 上海 200011
  • 出版日期:2011-08-28 发布日期:2011-08-29
  • 通讯作者: 瞿 佳, 电子信箱: jqu@wz.zj.cn。
  • 作者简介:周激波(1969—), 男, 副主任医师, 博士；电子信箱: zhoujibo1000@yahoo.com.cn。
  • 基金资助:

    上海市重点学科建设项目(S30205)；上海交通大学医学院基金（YZ1022）

Relationship between myopia and eyeball and systemic immune inflammation

ZHOU Ji-bo1,2, QU Jia1   

  1. 1.Optical Research Center of the Ministry of Health of China, Wenzhou 325027, China；2.Department of Ophthalmology, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2011-08-28 Published:2011-08-29
  • Supported by:

    Shanghai Leading Academic Discipline Project, S30205；Shanghai Jiaotong University School of Medicine Foundation, YZ1022

PDF (PC)

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摘要：

炎症是人类最基本的病理生理过程之一，波及巩膜的炎症常导致近视的发生，炎症可能源自全身其他组织和器官，也可能源自巩膜、脉络膜、视网膜及其周围组织。其可能的发病机制是：炎症因子的释放导致巩膜胶原降解，巩膜生物力学特性发生变化，在眼内压的作用下，眼轴延长，发生近视。明确近视与炎症的关系可以完善近视的病因学说，加深对于近视发病机制的认识，同时有助于进行正确的临床诊断和制定科学合理的眼病诊疗方案。

关键词: 近视, 炎症, 巩膜, 金属基质蛋白酶2

Abstract:

Inflammation is one of the basic pathophysiological processes of human beings, and inflammation involving sclera often results in myopia. Inflammation may derive from the other tissues and organs, or from sclera, choroid, retina and surrounding tissues. The possible pathogenesis may be that sclera thinning is caused by the release of inflammation factors, and myopia is developed by the lengthening of vitreous chamber of ocular globe. To interpret the relationship between myopia and inflammation may accomplish the etiology of myopia, enhance the understanding of pathogenesis of myopia, and help to diagnose and treat the disease properly.

Key words: myopia, inflammation, sclera, matrix metalloproteinase-2