›› 2011, Vol. 31 ›› Issue (9): 1328-.doi: 10.3969/j.issn.1674-8115.2011.09.027

• 综述 • 上一篇    下一篇


徐元林, 王 伟   

  1. 上海交通大学 医学院附属上海儿童医学中心心胸外科, 上海 200127
  • 出版日期:2011-09-28 发布日期:2011-09-27
  • 通讯作者: 王 伟, 电子信箱: wangweicpb@yahoo.com。
  • 作者简介:徐元林(1988—), 男, 硕士生;电子信箱: xuyuanlin_00@hotmail.com。

Clinical application of heart ischemic preconditioning and postconditioning

XU Yuan-lin, WANG Wei   

  1. Department of Cardiovascular and Thoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2011-09-28 Published:2011-09-27



关键词: 心脏, 缺血预处理, 缺血后处理


Heart ischemic preconditioning and postconditioning may have a protective effect against ischemia-reperfusion injury. Heart ischemic preconditioning can improve myocardial tolerance to ischemia, reduce myocardial infarct size, protect endothelial function, and is associated with significant reduction in ventricular arrhythmias, inotrope requirement and intensive care unit stay. Ischemic postconditioning may attenuate cardiomyocyte apoptosis and improve the recovery of left ventricular systolic function. This article focuses on the clinical application, main mechanism and influencing factors of heart ischemic preconditioning and postconditioning.

Key words: heart, ischemic preconditioning, ischemic postconditioning