上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (2): 231-.doi: 10.3969/j.issn.1674-8115.2012.02.023

• 综述 • 上一篇    下一篇

叶黄素在眼科疾病中作用和机制的实验性研究进展

张 薇1,2, 童念庭2, 尹莉莉2, 宫媛媛2, 吴星伟1,2   

  1. 1.上海交通大学医学院, 上海 200025；2.上海交通大学附属第一人民医院眼科, 上海 200080
  • 出版日期:2012-02-28 发布日期:2012-02-28
  • 通讯作者: 吴星伟, 电子信箱: wxweye@sina.com。
  • 作者简介:张 薇（1984—）, 女, 博士生；电子信箱: zwhappy@sjtu.edu.cn。
  • 基金资助:

    上海市眼底病重点实验室开放课题基金（07Z22911）

Laboratory research progress of roles and mechanisms of lutein in eye diseases

ZHANG Wei1,2, TONG Nian-ting2, YIN Li-li2, GONG Yuan-yuan2, WU Wing-wei1,2   

  1. 1.Shanghai Jiaotong University School of Medicine, Shanghai 200025；2.Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2012-02-28 Published:2012-02-28
  • Supported by:

    Shanghai Key Laboratory for Ocular Fundus Diseases Foundation, 07Z22911

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摘要：

叶黄素可清除单氧基团和过氧化自由基，对视网膜的保护机制主要体现为滤过蓝光和抗氧化损伤。叶黄素在多种眼科疾病中的预防及治疗作用虽被临床证明有效，但其机制尚未完全明确，有待临床与基础研究探索。文章对叶黄素在眼科疾病中作用和机制的实验性研究进展进行综述，主要介绍常见眼科疾病动物模型中和眼科相关细胞中叶黄素的研究。

关键词: 叶黄素, 动物模型, 细胞实验, 抗氧化

Abstract:

Lutein has been proved to have the ability to remove singlet oxygen groups and peroxide radicals, and it protects human retina from injury through blue-light infiltration and antioxidation. Although the validity of lutein to prevent or treat various eye diseases has been revealed by clinical trials, the exact mechanism is not definitely known, which leaves room for clinical and laboratory researches. The laboratory research progress of roles and mechanisms of lutein in eye diseases is reviewed in this paper, and major eye diseasesassociated animal models and cells in laboratory researches for lutein are introduced.

Key words: lutein, animal model, cell experiment, antioxidation