上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (5): 679-.doi: 10.3969/j.issn.1674-8115.2012.05.033

• 综述 • 上一篇    下一篇

端粒、线粒体和干细胞衰老

黄黎亚, 陈书艳   

  1. 上海交通大学 医学院附属新华医院老年医学科, 上海 200092
  • 出版日期:2012-05-28 发布日期:2012-06-01
  • 通讯作者: 陈书艳, 电子信箱: shuyanchencn@yahoo.com.cn。
  • 作者简介:黄黎亚(1979—), 女, 硕士生；电子信箱: liya_66@hotmail.com。

Telomeres, mitochondria and stem cell aging

HUANG Li-ya, CHEN Shu-yan   

  1. Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2012-05-28 Published:2012-06-01

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摘要：

干细胞是一类在所有生命周期中具有关键性作用的特殊细胞，保持干细胞活力、延缓干细胞衰老及延长干细胞寿命具有重要意义。该文从基因组维护和端粒、细胞周期抑制因子、线粒体等几个方面对干细胞衰老的分子机制作一整体性综述，侧重于端粒-p53通路和线粒体-活性氧自由基途径间的关系及其对干细胞衰老的影响。

关键词: 干细胞, 衰老, 端粒, p53, 线粒体, 活性氧自由基

Abstract:

Stem cells are the special cells which play a key role in the whole life cycle. It is very important to maintain the activity of stem cells, slow down stem cell aging and prolong the life of stem cells. In this paper, the molecular mechanism of stem cell aging is reviewed from the aspects including genome maintenance, telomeres, cell cycle inhibitors and mitochondria. The relationship between telomere-p53 pathway and mitochondria-reactive oxygen species pathway is focused, and the impacts of the two pathways on stem cell aging are introduced.

Key words: stem cell, aging, telomere, p53, mitochondria, reactive oxygen species