上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (8): 1014-.doi: 10.3969/j.issn.1674-8115.2012.08.012

• 专题报道（不孕不育症及辅助生殖技术） • 上一篇    下一篇

子宫内膜容受性标志物的研究进展

张平贵, 冯 云   

  1. 上海交通大学 医学院附属瑞金医院生殖医学中心, 上海 200025
  • 出版日期:2012-08-28 发布日期:2012-08-29
  • 作者简介:张平贵（1986—）, 女, 硕士；电子信箱: zhangpinggui86@126.com。

Research progress of endometrial receptivity markers

ZHANG Ping-gui, FENG Yun   

  1. Reproductive Medical Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-08-28 Published:2012-08-29

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摘要：

低种植率始终是生殖医学领域尚未解决的难题之一，也是限制人类辅助生殖技术发展的瓶颈问题。胚胎的成功着床取决于胚泡的侵入能力和子宫内膜容受性。然而，大量的临床试验发现即使胚胎质量良好，胚胎的种植率仍然较低。子宫内膜容受性受损可能是导致低种植率的主要因素。良好的内膜容受态的建立能促进胚胎与内膜的相互作用，利于胚胎着床。明确子宫内膜容受性标志物是改善内膜容受性的前提条件。近年来，对子宫内膜容受性的研究成为生殖领域的热点，该文主要对内膜容受性的经典标志物如胞饮突、白血病抑制因子（LIF）、同源框A 10（HOXA10）基因等作一综述。

关键词: 体外受精-胚胎移植, 胚胎种植, 内膜容受性, 标志物

Abstract:

The low implantation rate is one of the major issues in the field of reproductive medicine, which has not been solved nowadays, and it also remains the major rate-limiting step in the development of human-assisted reproductive technology. Successful implantation requires a vital embryo and receptive endometrium. However, a large number of clinical trials have found that even if the embryo quality is good, the embryo implantation rate is continued low. The endometrium receptivity damage may be the main factor leading to low implantation rate. The better establishment of endometrial receptivity state may promote embryo-endometrial cross-talk, allowing the embryo implantation. The identification of endometrial receptivity markers is a prerequisite for improving endometrial receptivity. In recent years, the assessment of endometrial receptivity has become a research hotspot in reproductive medicine. The endometrial receptivity markers such as pinopodes, leukemia inhibitory factor (LIF) and homeobox A10 (HOXA10) gene are introduced in this paper.

Key words: in vitro fertilization-embryo transfer, embryo implantation, endometrial receptivity, marker