Abstract:

Objective To observe the effect of cisatracurium on rapid tracheal intubation and intubation conditions in children under anesthesia with fentanyl and propofol. Methods Sixty children scheduled for adenotonsillectomy were randomly divided into group Ⅰ(0.1 mg/kg cisatracurium), group Ⅱ(0.15 mg/kg cisatracurium) and group Ⅲ (0.6 mg/kg rocuronium) according to muscle relaxant types and doses, with 20 children in each group. Anesthesia was induced with propofol, fentanyl and corresponding doses of muscle relaxant. Tracheal intubation was attempted 1 min after administration of muscle relaxant. Neuromuscular block was assessed by monitoring the electromyographic response of the adductor pollicis response to train-of-four (TOF) stimulations. The first twitch response (T1) and onset time (time from administration of muscle relaxant to maximal depression of T1) were recorded. Intubation conditions were evaluated. Results The scores of intubation conditions in group Ⅱ and group Ⅲ were significantly better than that in group Ⅰ 1 min after administration of muscle relaxant (P＜0.05), while there was no significant difference between group Ⅱ and group Ⅲ (P＞0.05). The maximal neuromuscular block effects of T1 were not achieved in three groups at the time of intubation. Maximum suppression of T1 in group Ⅱ and group Ⅲ was significantly shorter than that in group Ⅰ（P＜0.05）, time of action of muscle relaxant in group Ⅱ and group Ⅲ was significantly faster than that in group Ⅰ（P＜0.05）, while no significant difference was found between group Ⅱ and group Ⅲ (P＞0.05). Conclusion Favorable rapid tracheal intubation conditions can be obtained 1 min after administration of 0.15 mg/kg cisatracurium under anesthesia with fentanyl and propofol in children.

Key words: cisatracurium, rapid tracheal intubation, children