›› 2013, Vol. 33 ›› Issue (2): 235-.doi: 10.3969/j.issn.1674-8115.2013.02.022

• Review • Previous Articles     Next Articles

Research progress of transplantation of mesenchymal stem cells in treatment of immunological diseases

GONG Fei-xiang1, WANG Yang2, DENG Zhi-feng3   

  1. 1.Department of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China； 2.Institute of Orthopaedic Trauma, Shanghai Jiaotong University, Shanghai 200233, China； 3.Department of Neurosurgery, the Sixth People´s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2013-02-28 Published:2013-03-07
  • Supported by:

    National Natural Science Foundation of China, 81060324

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Abstract:

Mesenchymal stem cells (MSCs), a subset of adult stem cells, possess multilineage differentiation potential and low immunogenicity. MSCs can promote angiogenesis, cell replacement therapy and neuroprotection. It has also been revealed that MSCs have immunomodulatory properties: inhibition of T cell proliferation, suppression of B cell proliferation and differentiation, modulation of natural killer cell activity and influencing dendritic cell maturation and function. Recent studies have demonstrated that transplantation of MSCs can effectively treat immunological diseases, such as graft-versus-host disease, rheumatoid arthritis, diabetes and multiple sclerosis. The research progress of transplantation of MSCs in treatment of immunological diseases is reviewed in this paper.

Key words: mesenchymal stem cell, immunomodulation, immunological disease