›› 2013, Vol. 33 ›› Issue (5): 690-.doi: 10.3969/j.issn.1674-8115.2013.05.037

• Review • Previous Articles     Next Articles

Influencing factors of reproducibility on establishment of Olanzapine-induced metabolic disorder animal model

ZHANG Cheng-fang1, Dake Qi2, CUI Dong-hong1   

  1. 1.Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China； 2.Department of Internal Medicine, Yale University School of Medicine, New Haven 06520, USA
  • Online:2013-05-28 Published:2013-05-28
  • Supported by:

    Shanghai Pujiang Talent Program, 10PJ1408800； National Natural Science Foundation, 81171266； Shanghai Science and Technology Innovation Program, 11140900400； Foundation of the Ministry of Education of China for Returned Talents from Overseas； Shanghai Public Health Excellent Discipline Leader Program, GWDTR201230； National Natural Science Foundation of China, 81271481

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Abstract:

Olanzapine-induced metabolic disorders have been increasingly concerned. However, the mechanism is still unknown. The establishment of an appropriate animal model to explore the mechanism is a most important way, and the stability and reproducibility of an animal model are of vital importance. In this paper, the studies on establishment of Olanzapine-induced metabolic disorder animal models are reviewed, and the influencing factors of the reproducibility of animal models are discussed, hoping to provide reference for the related research.

Key words: Olanzapine, metabolic disorder, animal model, reproducibility