›› 2015, Vol. 35 ›› Issue (10): 1516-.doi: 10.3969/j.issn.1674-8115.2015.10.017

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Correlation between cognitive function and symptom changes of patients with schizophrenia

CAO Ai-ai 1,2, ZHANG Jie1, HUANG Jia1, ZHU Na1, ZHANG Tian-hong1, GAO Rong-xin1, ZHANG Li1, QIU Mei-hui1, PENG Dai-hui1, XU Yi-feng1   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China; 2.Shanghai Changning District Mental Health Center, Shanghai200335, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    Foundation of Shanghai Municipal Health Bureau, 2010086， 2011-2013; Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University, YG2012MS11

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Abstract:

ObjectiveTo explore the correlation between characteristics of the cognitive function and changes of clinical symptoms of patients with schizophrenia by follow-up of the cognitive function study of patients with schizophrenia after treatment.MethodsA total of 30 patients with schizophrenia of first episode who met the criteria of ICD-10 were enrolled. All patients were treated with risperidone. MATRICS consensus cognitive battery (MCCB) tool was used to test all seven dimensions of the cognitive function and Positive and Negative Syndrome Scale (PANSS) was adopted to assess mental symptoms of patients.MCCB test and PANSS assessment were conducted after one year of follow-up.ResultsA total of 19 patients were followed up for one year. The differences of verbal learning and memory of patients with schizophrenia before and after treatment were statistically significant (P<0.05). Changes of other six dimensions of the cognitive function were not statistically significant. The positive, negative, and general psychopathological symptoms of patients with schizophrenia were significantly alleviated one year after treatment (P<0.05). The preemptive concept and active social withdrawal of the general psychopathological factor of clinical symptoms positively correlated with verbal learning and memory of cognitive function (P<0.05). ConclusionThe verbal learning and memory of patients with schizophrenia have changed before and after treatment, which are relevant to the changes of preemptive concept and active social withdrawal.

Key words: schizophrenia, cognitive function, MATRICS consensus cognitive battery