›› 2015, Vol. 35 ›› Issue (10): 1569-.doi: 10.3969/j.issn.1674-8115.2015.10.028

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Research progresses of animal models of cognitive impairment of patients with schizophrenia

LIN Ye-zhe1, CUI Dong-hong2   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China; 2.Shanghai Key Laboratory of Psychotic Disorders, Shanghai201108, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Nature Science Foundation of China, 81171266, 81271481; Project of Shanghai Science and Technology Innovation， 11140900400; Shanghai Key Laboratory of Psychotic Disorders, 13dz2260500

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Abstract:

Cognitive impairment of patients with schizophrenia has attracted many attentions due to its severe effect on patients’ social function. The existing treatments of cognitive impairment of patients with schizophrenia are not effective and extensive researches are needed to solve this problem. However, due to limitations of research methods, researches of this area are limited. Animal models are effective tools that can mimic the cognitive impairment of patients with schizophrenia and complement the disadvantage that researches cannot be carried out on human beings. This paper reviews research progresses of mimicking the cognitive impairment of patients with schizophrenia by using laboratory animals and provides ideas for studying and alleviating the cognitive impairment of patients with schizophrenia.

Key words: schizophrenia, cognitive impairment, animal models