›› 2018, Vol. 38 ›› Issue (8): 948-.doi: 10.3969/j.issn.1674-8115.2018.08.015

• Review • Previous Articles     Next Articles

Research progress of role of Pi3k/Akt pathway in mechanism of atypical antipsychotic drugs

CHEN Yan, ZHANG Chen   

  1. Department of Biochemistry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2018-08-28 Published:2018-09-11
  • Supported by:
    National Natural Science Foundation of China, 81000581, 81471358, 81771450; National Key Clinical Discipline at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Science and Technology Development Funds, 12140904200; Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20152530)。

Abstract: The alterations of Pi3k/Akt pathway may be critical in the pathogenesis of schizophrenia. Furthermore, atypical antipsychotic drugs can modify Pi3k/Akt pathway, which have been received wide attention. This review mainly focused on four aspects, i.e. metabolic syndrome, changes in immune function, cognitive impairment and neuroprotective effect, and summarized the research progress of role of Pi3k/Akt pathway in the mechanism of atypical antipsychotic drugs.

Key words: atypical antipsychotic drugs (AAPs), Pi3k/Aktpathway, schizophrenia, adverse reaction

CLC Number: