›› 2013, Vol. 33 ›› Issue (5): 690-.doi: 10.3969/j.issn.1674-8115.2013.05.037

• Review • Previous Articles     Next Articles

Influencing factors of reproducibility on establishment of Olanzapine-induced metabolic disorder animal model

ZHANG Cheng-fang1, Dake Qi2, CUI Dong-hong1   

  1. 1.Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China; 2.Department of Internal Medicine, Yale University School of Medicine, New Haven 06520, USA
  • Online:2013-05-28 Published:2013-05-28
  • Supported by:

    Shanghai Pujiang Talent Program, 10PJ1408800; National Natural Science Foundation, 81171266; Shanghai Science and Technology Innovation Program, 11140900400; Foundation of the Ministry of Education of China for Returned Talents from Overseas; Shanghai Public Health Excellent Discipline Leader Program, GWDTR201230; National Natural Science Foundation of China, 81271481


Olanzapine-induced metabolic disorders have been increasingly concerned. However, the mechanism is still unknown. The establishment of an appropriate animal model to explore the mechanism is a most important way, and the stability and reproducibility of an animal model are of vital importance. In this paper, the studies on establishment of Olanzapine-induced metabolic disorder animal models are reviewed, and the influencing factors of the reproducibility of animal models are discussed, hoping to provide reference for the related research.

Key words: Olanzapine, metabolic disorder, animal model, reproducibility