上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (11): 1377-.

• 综述 • 上一篇    下一篇

氧化应激对p53翻译后修饰影响的研究进展

孙祖俊, 综述；易静, 王毓美, 审校   

  1. 上海交通大学 基础医学院 细胞生物学教研室 教育部细胞分化与凋亡重点实验室, 上海 200025
  • 出版日期:2009-11-25 发布日期:2009-11-24
  • 作者简介:孙祖俊（1976—）, 男, 主管技师, 硕士生；电子信箱: sunyu0816@sina.com。
  • 基金资助:

    上海市自然科学基金(08ZR1412300)

Influence of oxidative stress on p53 post-translational modifications

SUN Zu-jun, reviewer；YI Jing, WANG Yu-mei, reviser   

  1. Department of Cell Biology, Key Laboratory of The Ministry of Education for Cell Differentiation and Apoptosis, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025,China
  • Online:2009-11-25 Published:2009-11-24
  • Supported by:

    Natural Science Foundation of Shanghai, 08ZR1412300

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摘要：

蛋白质翻译后修饰是调控蛋白质功能及影响细胞行为的重要方式，而氧化应激直接影响蛋白质的翻译后修饰。p53的翻译后修饰极为丰富，在细胞应激条件下p53的多种翻译后修饰被快速调节，从而激活一系列下游靶基因，使p53 呈现功能的多样性。文章着重阐述氧化应激对p53磷酸化、泛素化、SUMO化、乙酰化和甲基化等不同翻译后修饰的影响。

关键词: 氧化应激, p53, 翻译后修饰

Abstract:

Protein post-translational modifications are important ways to regulate protein function and cell behavior, and oxidative stress directly influences protein post-translational modifications. p53 protein has various post-translational modifications, which can be quickly regulated under stress conditions to activate a series of downstream target genes and facilitate the p53 function diversity.The effects of oxidative stress on p53 post-translational modifications of phosphorylation, ubiquitination, sumoylation, acetylation and methylation are introduced in this paper.

Key words: oxidative stress, p53, post-translational modification