上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (10): 1465-.doi: 10.3969/j.issn.1674-8115.2011.10.024

• 综述 • 上一篇    下一篇

成骨细胞分化及增殖调控的研究进展

王勇平, 欧阳元明, 蒋 垚   

  1. 上海交通大学附属第六人民医院骨科, 上海 200233
  • 出版日期:2011-10-28 发布日期:2011-10-27
  • 通讯作者: 蒋 垚, 电子信箱: jiangyao195106@163.com。
  • 作者简介:王勇平（1976—）, 男, 主治医师, 博士；电子信箱: wangyp312@163.com。

Research progress of regulation of osteoblast differentiation and proliferation

WANG Yong-ping, OUYANG Yuan-ming, JIANG Yao   

  1. Department of Orthopedics, the Sixth people's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2011-10-28 Published:2011-10-27

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摘要：

在骨代谢与骨改建过程中，间充质细胞在一定条件下分化为成骨细胞，使新骨生成，正常骨改建和部分骨病理性改变与成骨细胞的分化和增殖功能的关系密切。成骨细胞在分化和增殖过程中受许多全身和局部调节因子的精细调控，本文就成骨细胞分化和增殖过程调控因素的研究进展作一综述。

关键词: 成骨细胞, 分化, 增殖, 调控

Abstract:

During bone metabolism and bone remodeling, mesenchymal cells differentiate into osteoblasts under certain conditions, which play an important role in bone formation. The normal bone remodeling and part of the bone pathological changes are closely related to osteoblast differentiation and proliferation. Osteoblast differentiation and proliferation are regulated by a variety of systemic and regional factors. Recent progress of regulation of osteoblast differentiation and proliferation is reviewed in this paper.

Key words: osteoblast, differentiation, proliferation, regulation