上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (4): 510-.doi: 10.3969/j.issn.1674-8115.2011.04.030

• 综述 • 上一篇    下一篇

异位子宫内膜17β-羟基类固醇脱氢酶2缺乏的分子机制

李笛悠, 张 萍   

  1. 上海交通大学 医学院附属新华医院妇产科, 上海 200092
  • 出版日期:2011-04-28 发布日期:2011-04-28
  • 作者简介:李笛悠(1986—), 女, 硕士生；电子信箱: lidiyou_u@163.com。

Mechanism of 17 β-hydroxysteroid dehydrogenase-2 deficiency in ectopic endometrium

LI Di-you, ZHANG Ping   

  1. Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-04-28 Published:2011-04-28

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摘要：

正常子宫内膜凋亡受雌激素的影响，17β-羟基类固醇脱氢酶2（17β-HSD2）在调控雌激素生物活性中起主要作用，其量和活性依赖孕激素的调控，孕激素通过与孕激素受体结合起作用。在子宫内膜异位症患者的异位内膜中，17β-HSD2表达下降。文章综述17β-HSD2对雌激素活性的调控及对子宫内膜生长的调节，以及17β-HSD2的表达与孕激素及其相应受体结构、基因、亚型、功能的相关性，并探讨17β-HSD2在子宫内膜异位症的发生、发展、治疗、预后中的作用。

关键词: 子宫内膜异位症, 17β-羟基类固醇脱氢酶2, 雌激素, 孕激素, 孕激素受体, 维甲酸, 代谢

Abstract:

The apoptosis of normal endometrium is affected by estrogen. The biological activity of estrogen is mainly adjusted by 17β-hydroxysteroid dehydrogenase-2 (17β-HSD2), whose activity and quantity are dependent on progesterone that works in combination with its receptors. However, 17β-HSD2 is decreased in the ectopic endometrium of patients with endometriosis. This review is to introduce the paths how 17β-HSD2 inactivates estradiol and adjusts the growth of endometrium, and the relationship between the expression of 17β-HSD2 and the formation, gene, isoforms and function of progesterone and progesterone receptor, based on which the significance of 17β-HSD2 in the genesis, development, treatment and prognosis of endometriosis is discussed.

Key words: endometriosis, 17β-hydroxysteroid dehydrogenase-2, estrogen, progesterone, progesterone receptor, retinoic acid, metabolism