上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (2): 235-.doi: 10.3969/j.issn.1674-8115.2013.02.022

• 综述 • 上一篇    下一篇

间充质干细胞移植治疗免疫性疾病的研究进展

龚飞翔1, 汪 泱2, 邓志锋3   

  1. 1.南昌大学 第二附属医院神经外科, 南昌 330006； 2.上海交通大学创伤骨科研究所, 上海 200233； 3.上海交通大学附属第六人民医院神经外科, 上海 200233
  • 出版日期:2013-02-28 发布日期:2013-03-07
  • 通讯作者: 邓志锋, 电子信箱: dengzf63@126.com。
  • 作者简介:龚飞翔(1986—）, 男, 硕士生；电子信箱: gongfeixiang860225@126.com。
  • 基金资助:

    国家自然科学基金（81060324）

Research progress of transplantation of mesenchymal stem cells in treatment of immunological diseases

GONG Fei-xiang1, WANG Yang2, DENG Zhi-feng3   

  1. 1.Department of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China； 2.Institute of Orthopaedic Trauma, Shanghai Jiaotong University, Shanghai 200233, China； 3.Department of Neurosurgery, the Sixth People´s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2013-02-28 Published:2013-03-07
  • Supported by:

    National Natural Science Foundation of China, 81060324

PDF (PC)

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摘要：

间充质干细胞（MSCs）是一类具有多向分化潜能和低免疫原性的成体干细胞，具有促进血管形成、保护神经和细胞替代治疗作用，此外，MSCs还具有免疫调节功能，如抑制T细胞增殖和B细胞增殖分化、调节自然杀伤性细胞活性和树突状细胞成熟及功能等。最新研究表明，移植MSCs能有效治疗免疫性疾病如移植物抗宿主病、类风湿性关节炎、糖尿病和多发性硬化症等，文章就MSCs移植治疗免疫相关性疾病的研究进展进行综述。

关键词: 间充质干细胞, 免疫调节, 免疫性疾病

Abstract:

Mesenchymal stem cells (MSCs), a subset of adult stem cells, possess multilineage differentiation potential and low immunogenicity. MSCs can promote angiogenesis, cell replacement therapy and neuroprotection. It has also been revealed that MSCs have immunomodulatory properties: inhibition of T cell proliferation, suppression of B cell proliferation and differentiation, modulation of natural killer cell activity and influencing dendritic cell maturation and function. Recent studies have demonstrated that transplantation of MSCs can effectively treat immunological diseases, such as graft-versus-host disease, rheumatoid arthritis, diabetes and multiple sclerosis. The research progress of transplantation of MSCs in treatment of immunological diseases is reviewed in this paper.

Key words: mesenchymal stem cell, immunomodulation, immunological disease