上海交通大学学报（医学版）

上海交通大学学报（医学版）

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自噬在大脑缺血再灌注损伤中作用的研究进展

汪文英，崔德荣，江 伟   

  1. 上海交通大学附属第六人民医院麻醉科， 上海 200233
  • 出版日期:2014-02-28 发布日期:2014-03-25
  • 通讯作者: 江 伟, 电子信箱: jjjww5@hotmail.com。
  • 作者简介:汪文英（1989—）， 女， 硕士生; 电子信箱: wenying_wang@163.com。

Advances of role of autophagy in cerebral ischemia-reperfusion injury

WANG Wen-ying, CUI De-rong, JIANG wei   

  1. Department of Anesthesiology, the Sixth People′s Hospital，Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2014-02-28 Published:2014-03-25

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摘要：

大脑缺血性疾病在中国是致死致残的最主要疾病之一，主要原因是高血压所致的血栓形成及血栓栓塞，其治疗原则是及时恢复缺血区的血液灌注，但是在某些情况下缺血后恢复血流并不能恢复组织功能，反而使组织损伤及功能障碍更加严重，即缺血再灌注损伤，其发生将导致严重的组织损伤及器官功能异常，因而成为一个十分重要而棘手的临床问题。了解缺血再灌注过程中促进或阻碍神经元死亡的机制对于解决这一健康难题十分重要。关于大脑缺血再灌注损伤的机制有多种，本文将重点介绍自噬在大脑缺血再灌注损伤中的调节机制及发挥的作用。

关键词: 大脑缺血, 再灌注损伤, 自噬

Abstract:

Diseases related to cerebral ischemia are main causes of mortality and morbidity in China. Most of them are mainly caused by hypertension associated thrombosis and thrombus embolism. The principle of cerebral ischemia treatment is to promptly restore blood perfusion of the ischemic area. But in some cases, the restoration of blood flow after ischemia can not restore tissue functions, instead tissue damage and dysfunction are more serious, namely ischemia-reperfusion (I/R) injury. So to better understand the mechanism of promoting or preventing neuron death during ischemia-reperfusion injury is critical. The article mainly reports new studies on autophagy about its regulation and roles in cerebral I/R injury.

Key words: cerebral ischemia, reperfusion injury, autophagy