上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (2): 217-.doi: 10.3969/j.issn.1674-8115.2018.02.019

• 综述 • 上一篇    下一篇

NLRP3 炎症小体在抑郁症发病机制中的作用

邢梦娟，彭代辉   

  1. 上海交通大学 医学院附属精神卫生中心，上海市重性精神病重点实验室，上海 200030
  • 出版日期:2018-02-28 发布日期:2018-03-09
  • 作者简介:?邢梦娟（1983—），女，住院医师，硕士；电子信箱：xingmj0209@sina.com。
  • 基金资助:
     国家自然科学基金面上项目（81571327）；上海市卫生和计划生育委员会项目（201640003）；上海市精神卫生中心院级课题（2017-YJ-15）

Research progress of NLRP3 inflammasome in the pathogenesis of depression disorder

XING Meng-juan, PENG Dai-hui   

  1. Shanghai Key Laboratory of Severe Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2018-02-28 Published:2018-03-09
  • Supported by:
    General Program of National Natural Science Foundation of China, 81571327; Shanghai Health and Family Planning Commission Program, 201640003; Shanghai Mental Health  Center Program, 2017-YJ-15

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摘要： 抑郁症是一种严重的精神疾病，给个人和社会带来了严重的健康风险与经济负担。目前有关抑郁症发病机制的理论众多，如神经递质紊乱、内分泌失调、神经元适应性和可塑性损害、氧化应激和线粒体功能障碍等。近年来，关于免疫功能异常在抑郁症发病中的研究日益增多，该文就天然免疫因子 NLRP3 炎症小体在抑郁症发病机制中作用的研究进展进行综述.

关键词: 抑郁症, 发病机制, NLRP3 炎症小体, 细胞因子

Abstract:

Depression disorder is a kind of serious mental illness which poses high health risks and heavy financial burden to individuals and the society. Currently, there are many theories on the pathogenesis of depression disorder, such as neurotransmitter disorders, endocrine disorders, abnormal neuronal adaptability and plasticity, oxidative stress and mitochondrial dysfunction and so on. In the lately decade, the research of immune dysfunction in the pathogenesis of depression has become a newly hot-point. This review summarizes NLRP3 inflammasome in the pathogenesis of depression disorder.

Key words:  depression disorder, pathogenesis mechanism, NLRP3 inflammasome, cytokine