糖尿病患者血糖波动异常与认知功能障碍关系的研究进展

doi:10.3969/j.issn.1674-8115.2022.02.016

上海交通大学学报(医学版) ›› 2022, Vol. 42 ›› Issue (2): 235-240.doi: 10.3969/j.issn.1674-8115.2022.02.016

• 综述 • 上一篇

糖尿病患者血糖波动异常与认知功能障碍关系的研究进展

张蓉¹(), 陆丽¹(), 王亚昕², 董文倩¹, 张宇¹, 周健²()

^1.上海交通大学医学院，上海 200025
^2.上海交通大学医学院附属第六人民医院内分泌代谢科，上海市糖尿病研究所，上海市糖尿病重点实验室，上海市糖尿病临床医学中心，上海 200233

收稿日期:2021-08-31 出版日期:2022-01-24 发布日期:2022-01-24
通讯作者: 周健 E-mail:517713910016@sjtu.edu.cn;zhoujian@sjtu.edu.cn
作者简介:张蓉（1998—），女，本科生；电子信箱：517713910016@sjtu.edu.cn
张蓉（1998—），女，本科生；电子信箱：517713910016@sjtu.edu.cn
基金资助:
上海市教育委员会高峰高原学科建设计划(20161430);上海市“医苑新星”青年医学人才培养资助计划-杰出青年医学人才类

Research progress in the relationship between abnormal blood glucose fluctuation and cognitive dysfunction of patients with diabetes mellitus

Rong ZHANG¹(), Li LU¹(), Yaxin WANG², Wenqian DONG¹, Yu ZHANG¹, Jian ZHOU²()

^1.Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
^2.Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China

Received:2021-08-31 Online:2022-01-24 Published:2022-01-24
Contact: Jian ZHOU E-mail:517713910016@sjtu.edu.cn;zhoujian@sjtu.edu.cn
Supported by:
Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20161430);Shanghai "Rising Stars of Medical Talent" Youth Development Program-Outstanding Youth Medical Talents

摘要/Abstract

摘要：

糖尿病不仅可导致大血管和微血管发生病变，还会加速认知功能障碍的发生与发展，增加罹患痴呆的风险。研究表明，糖尿病所致认知功能障碍与血糖升高及血糖波动异常均相关，其发病机制可能与胰岛素抵抗、氧化应激、脑血管病变、炎症损伤、脑细胞凋亡以及β淀粉样蛋白聚集等有关。目前，关于糖尿病患者认知功能障碍的药物治疗仍处于探索阶段，有研究发现部分降糖药物（如胰高血糖素样肽-1受体激动剂）或可改善该类患者的认知功能障碍，但仍需大样本随机对照研究进一步明确。该文对认知功能障碍的评估方法，血糖波动异常对认知功能障碍的影响和相关病理生理机制，以及不同降糖药物对糖尿病患者认知功能障碍的作用进行综述。

关键词: 糖尿病, 认知功能障碍, 血糖波动异常, 降糖药物

Abstract:

Diabetes can not only cause pathological changes in both large vessels and microvessels, but also accelerate the occurrence and development of cognitive dysfunction, increasing the risk of dementia. Studies have shown that diabetes-induced cognitive dysfunction is associated with elevated blood glucose and abnormal glucose fluctuation, and its pathogenesis is closely related to insulin resistance, oxidative stress, cerebrovascular lesions, inflammatory damage, brain cell apoptosis, as well as amyloid β-protein accumulation. At present, drug therapy for diabetic patients with cognitive dysfunction is still in the exploratory stage. It has been found that some hypoglycemic drugs, such as glucagon like peptide -1 receptor agonist, can improve cognitive dysfunction in these patients. However, it still needs to be further clarified by randomized controlled trails with large sample size. This article reviews the assessment methods of cognitive dysfunction, the effects of abnormal glucose fluctuation on cognitive dysfunction, and the pathophysiological mechanisms involved, as well as the effects of different hypoglycemic agents on cognitive dysfunction in patients with diabetes.

Key words: diabetes mellitus, cognitive dysfunction, abnormal blood glucose fluctuation, hypoglycemic agent

中图分类号:

R587.1

张蓉, 陆丽, 王亚昕, 董文倩, 张宇, 周健. 糖尿病患者血糖波动异常与认知功能障碍关系的研究进展[J]. 上海交通大学学报(医学版), 2022, 42(2): 235-240.

Rong ZHANG, Li LU, Yaxin WANG, Wenqian DONG, Yu ZHANG, Jian ZHOU. Research progress in the relationship between abnormal blood glucose fluctuation and cognitive dysfunction of patients with diabetes mellitus[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2022, 42(2): 235-240.

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糖尿病患者血糖波动异常与认知功能障碍关系的研究进展

Research progress in the relationship between abnormal blood glucose fluctuation and cognitive dysfunction of patients with diabetes mellitus

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