上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（基础研究） • 上一篇    下一篇

坎地沙坦对慢性束缚应激诱导的大鼠抑郁样行为的作用

曹爽1，杜勤1，李炳2，袁丽粉1，丁建伟3   

  1. 1.上海交通大学 医学院附属第九人民医院， 上海 200011； 2.复旦大学附属金山医院， 上海 201508； 3.复旦大学附属华东医院， 上海 200040
  • 出版日期:2016-04-28 发布日期:2016-05-26
  • 作者简介:曹爽（1988—）， 女， 住院医师， 硕士; 电子信箱: caoshuang2209@163.com。
  • 基金资助:

    上海交通大学医学院附属第九人民医院基金

Effect of candesartan on chronic restraint stress-induced depression-like behaviors in rats

CAO Shuang1, DU Qin1, LI Bing2, YUAN Li-fen1, DING Jian-wei3   

  1. 1．Shanghai Ninth Peoples Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai 200011， China; 2.Jinshan Hospital, Fudan University, Shanghai 201508, China； 3．Huadong Hospital, Fudan University, Shanghai 200040, China
  • Online:2016-04-28 Published:2016-05-26
  • Supported by:

    Foundation of Shanghai Ninth Peoples Hospital， Shanghai Jiao Tong University School of Medicine

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摘要：

目的 观察坎地沙坦对慢性束缚应激（CRS）诱导的大鼠抑郁样行为的改善作用，探索抗抑郁治疗的新靶点。方法 雄性Wistar大鼠24只，随机分为3组：空白对照组（n=8）、束缚应激组（n=8）和坎地沙坦组（n=8）。通过旷场实验（OFT）、糖水偏爱实验（SPT）及强迫游泳实验（FST）评估大鼠抑郁样行为。用ELISA法检测血浆促肾上腺皮质激素（ACTH）及血管紧张素Ⅱ（AngⅡ）水平。结果 坎地沙坦组与应激组比较，OFT中直立次数及水平位移显著升高（P=0.000），SPT中对糖水偏好程度增加（P=0.027），FST中不动时间缩短（P=0.000），血浆ACTH明显下降（P=0.000）。结论 坎地沙坦可改善CRS诱导的大鼠抑郁样行为。

关键词: 坎地沙坦, 慢性束缚应激, 抑郁

Abstract:

Objective To observe the effect of candesartan on improving chronic restraint stress (CRS)-induced depression-like behaviors in rats and explore novel targets for the treatment of depression. Methods Twenty-four male Wistar rats were randomly assigned to control group (n=8), stressed group (n=8), and candesartan group (n=8), respectively. Open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) were performed to evaluate depression-like behaviors in rats. ELISA was used to detect adrenocorticotropin hormone (ACTH) and aniotensin Ⅱ (AngⅡ) levels. Results Compared with the stressed group, rearing frequency and horizontal moving distance in OFT in the candesartan group significantly increased (P=0.000), sucrose preference percentage in SPT elevated (P=0.027), immobility time in FST reduced (P=0.000), and plasma ACTH level significantly decreased (P=0.000). Conclusion Candesartan can improve CRS-induced depression-like behaviors in rats.

Key words: candesartan, chronic restraint stress, depression