上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (6): 690-.doi: 10.3969/j.issn.1674-8115.2018.06.019

• 综述 • 上一篇    下一篇

自噬与非酒精性脂肪性肝病的研究进展

菅朝慧，包玉倩   

  1. 上海交通大学附属第六人民医院内分泌代谢科，上海市糖尿病临床医学中心，上海200233
  • 出版日期:2018-06-28 发布日期:2018-07-03
  • 作者简介:菅朝慧（1994—），女，博士生；电子信箱：jchsjtu@sjtu.edu.cn。
  • 基金资助:
    国家自然科学基金面上项目（31571212）

Research progress of autophagy in non-alcoholic fatty liver disease

JIAN Chao-hui, BAO Yu-qian   

  1. Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University; Shanghai Clinical Center for Diabetes, Shanghai 200233,China
  • Online:2018-06-28 Published:2018-07-03
  • Supported by:
    National Natural Science Foundation of China, 31571212

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摘要： 非酒精性脂肪性肝病是一种与胰岛素抵抗密切相关的代谢性肝损伤，目前已成为全球慢性肝病的首要病因，与2型糖尿病、动脉粥样硬化性心血管疾病的高发病率密切相关；该病可进展为肝硬化和肝细胞癌。非酒精性脂肪性肝病的发病机制复杂且尚未完全阐明。近年来研究发现自噬在非酒精性脂肪性肝病的发生、发展中发挥重要作用，主要通过调控胰岛素抵抗、内质网应激、线粒体调节异常、脂质沉积的脂毒性及炎症反应参与该病的发病与进展。

关键词: 自噬, 非酒精性脂肪性肝病, 脂质沉积, 胰岛素抵抗, 内质网应激, 线粒体调节异常, 炎症反应

Abstract:

Non-alcoholic fatty liver disease is a type of metabolic liver injury which is closely related to insulin resistance. Now it has become the leading caof chronic liver diseases worldwide, which is closely related to the high incidence of type 2 diabetes and arteriosclerotic cardiovascular disease. It can progress into cirrhosis and hepatocellular carcinoma. The pathogenesis of non-alcoholic fatty liver disease is complicated and not yet fully elucidated. In recent years, studies have found that autophagy plays an important role in the development of non-alcoholic fatty liver disease, mainly through regulation of insulin resistance, endoplasmic reticulum stress, mitochondrial dysregulation, lipid-toxicity causedlipid deposition and inflammation.

Key words: autophagy, non-alcoholic fatty liver disease, lipid deposition, insulin resistance, endoplasmic reticulum stress, mitochondrial dysregulation, inflammation

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