滤泡辅助性T细胞在自身免疫病中作用的研究进展

doi:10.3969/j.issn.1674-8115.2022.02.013

摘要/Abstract

摘要：

滤泡辅助性T细胞（follicular helper T cell，Tfh细胞）近年被定义为新的CD4⁺T细胞亚群，主要表达C-X-C趋化因子受体5、可诱导共刺激分子等表面分子，分泌细胞因子白细胞介素-21，其关键转录因子为B细胞淋巴瘤分子6。Tfh细胞存在于淋巴组织的生发中心及外周血中，可促进B细胞的成熟与分化、生发中心的形成及抗体的产生，在系统性红斑狼疮、类风湿性关节炎、原发性干燥综合征等多种自身免疫病的发病机制中发挥重要作用，Tfh细胞数量和（或）功能的异常参与组织损伤等病理过程，并促进疾病进展。该文就Tfh细胞的生物学特性以及其在不同类型自身免疫病中的作用进行了综述，为进一步揭示某些自身免疫病的发病机制提供参考，并为通过靶向该细胞来治疗疾病提供新的思路。

关键词: 滤泡辅助性T细胞, 自身免疫病, B细胞, 自身抗体, 白细胞介素-21

Abstract:

Follicular helper T cells (Tfh cells) have been defined as a new subset of CD4⁺T cells in recent years, mainly expressing surface molecules such as C-X-C motif chemokine receptor type 5, inducible co-stimulator, and secreting cytokine interleukin-21, a key transcription factor of which is B cell lymphoma 6. They exist in the germinal center (GC) of lymphoid tissue and in the peripheral blood as well. With the ability to promote B cell maturation and differentiation, GC formation and antibody production, Tfh cells play important roles in the pathogenesis of many autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and primary Sj?gren's syndrome. The abnormal quantity and/or quality of Tfh cells will cause pathological processes like tissue injury and promote disease progression. This article reviews the biological characteristics of Tfh cells and their roles in different autoimmune diseases, which may help to further reveal the pathogenesis of certain autoimmune diseases and provide a new way to treat these diseases by targeting these cells.

Key words: follicular helper T cell, autoimmune disease, B cell, autoantibody, interleukin-21

中图分类号:

R593.2

卫欣迪, 钮晓音. 滤泡辅助性T细胞在自身免疫病中作用的研究进展[J]. 上海交通大学学报(医学版), 2022, 42(2): 218-224.

Xindi WEI, Xiaoyin NIU. Research progress in roles of follicular helper T cells in autoimmune diseases[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2022, 42(2): 218-224.

图/表 1

参考文献 59

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