›› 2013, Vol. 33 ›› Issue (2): 225-.doi: 10.3969/j.issn.1674-8115.2013.02.020

• Review • Previous Articles     Next Articles

GPER: a novel target in treatment of estrogen-related diseases

WANG Jie1,2, Haji Akber AISA2, MA Hai-rong2, WANG Zhen-hua1   

  1. 1.Key Laboratory of Xinjiang Endemic Phytomedicine Resources, College of Pharmacy, Shihezi University, Shihezi 832002, China; 2.Key Laboratory of Plant Resources and Natural Products Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
  • Online:2013-02-28 Published:2013-03-07
  • Supported by:

    National Natural Science Foundation of China, 81102890, 30925045;Foundation of the Ministry of Education of China, NCET-10-0967


G protein-coupled estrogen receptor 1 (GPER) is a novel receptor, which belongs to the family of G protein-coupled receptors, to many of the rapid biological responses to estrogen. Different from the two classical nuclear estrogen receptors, ERα and ERβ, GPER modulates both rapid non-genomic reaction and genomic transcriptional events of estrogen. In this regard, GPER may be considered as a valuable target toward novel therapeutic strategy for many estrogen-related diseases. The intrinsic appearance of GPER, including structure, subcellular localization, ligands, signal transduction pathway and relationship with diseases is reviewed in this paper.

Key words: G protein-coupled estrogen receptor 1, gene expression, cancer