›› 2013, Vol. 33 ›› Issue (2): 225-.doi: 10.3969/j.issn.1674-8115.2013.02.020

• Review • Previous Articles     Next Articles

GPER: a novel target in treatment of estrogen-related diseases

WANG Jie1,2, Haji Akber AISA2, MA Hai-rong2, WANG Zhen-hua1   

  1. 1.Key Laboratory of Xinjiang Endemic Phytomedicine Resources, College of Pharmacy, Shihezi University, Shihezi 832002, China； 2.Key Laboratory of Plant Resources and Natural Products Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
  • Online:2013-02-28 Published:2013-03-07
  • Supported by:

    National Natural Science Foundation of China, 81102890, 30925045；Foundation of the Ministry of Education of China, NCET-10-0967

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Abstract:

G protein-coupled estrogen receptor 1 (GPER) is a novel receptor, which belongs to the family of G protein-coupled receptors, to many of the rapid biological responses to estrogen. Different from the two classical nuclear estrogen receptors, ERα and ERβ, GPER modulates both rapid non-genomic reaction and genomic transcriptional events of estrogen. In this regard, GPER may be considered as a valuable target toward novel therapeutic strategy for many estrogen-related diseases. The intrinsic appearance of GPER, including structure, subcellular localization, ligands, signal transduction pathway and relationship with diseases is reviewed in this paper.

Key words: G protein-coupled estrogen receptor 1, gene expression, cancer