左心室肥厚相关心血管病变影响阿尔茨海默病的研究进展

doi:10.3969/j.issn.1674-8115.2025.12.014

摘要/Abstract

摘要：

左心室肥厚是一种以左心室壁增厚、心肌质量增加为特征的心肌重塑现象，不仅与心力衰竭、冠状动脉粥样硬化性心脏病、心律失常等多种心血管疾病的发病和死亡密切相关，也被证实是认知功能障碍的独立危险因素。阿尔茨海默病作为最常见的神经退行性疾病，以进行性认知功能障碍和行为损害为特征。尽管心血管疾病与认知功能障碍的关系被广泛研究，但目前左心室肥厚影响阿尔茨海默病的核心病理机制尚未完全阐明。该文系统综述了阿尔茨海默病与心血管系统疾病的关系，以及左心室肥厚与阿尔茨海默病的共病性及其直接病理机制，以期为深入探讨心脑交互作用提供新视角。

关键词: 左心室肥厚, 阿尔茨海默病, 心血管疾病

Abstract:

Left ventricular hypertrophy (LVH) is a form of myocardial remodeling characterized by thickening of left ventricular wall and increased myocardial mass. It is not only associated with the incidence and mortality of various cardiovascular diseases such as heart failure, coronary artery disease, and arrhythmias, but is also considered an independent risk factor for cognitive dysfunction. Alzheimer's disease (AD), the most common cause of dementia, is a neurodegenerative disorder of the central nervous system characterized by progressive cognitive impairment and behavioral deficits. Although the relationship between cardiovascular diseases and cognitive dysfunction has been widely investigated, the mechanisms through which LVH affects the core pathology of AD are not yet fully elucidated. This article provides a comprehensive systematic overview regarding the relationship between AD and cardiovascular diseases, the comorbidity of LVH and AD, and their direct pathological mechanisms, offering novel perspectives for advancing the exploration of heart-brain axis interactions.

Key words: left ventricular hypertrophy, Alzheimer's disease, cardiovascular disease

中图分类号:

R741.02

罗宇琦, 王洋洋, 任骏. 左心室肥厚相关心血管病变影响阿尔茨海默病的研究进展[J]. 上海交通大学学报（医学版）, 2025, 45(12): 1679-1686.

LUO Yuqi, WANG Yangyang, REN Jun. Advances in research on left ventricular hypertrophy-associated cardiovascular pathology in Alzheimer' s disease[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(12): 1679-1686.

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