上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (1): 109-.doi: 10.3969/j.issn.1674-8115.2013.01.022

• 综述 • 上一篇    下一篇

多能干细胞与肾脏再生的研究进展

黄佳卉1, 汪 泱1,2, 王共先1   

  1. 1.南昌大学 第一附属医院泌尿外科研究所, 南昌 330006； 2.上海交通大学创伤骨科研究所, 上海 200233
  • 出版日期:2013-01-28 发布日期:2013-02-06
  • 通讯作者: 汪 泱, 电子信箱: wangy63cn@126.com。
  • 作者简介:黄佳卉（1984—）, 女, 硕士生；电子信箱: jiahuihuang33006@163.com。
  • 基金资助:

    国家自然科学基金（81170640, 30960385）

Research progress of pluripotent stem cells and kidney regeneration

HUANG Jia-hui1, WANG Yang1,2, WANG Gong-xian1   

  1. 1.Institute of Urology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China； 2.Institute of Orthopaedic Trauma, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2013-01-28 Published:2013-02-06
  • Supported by:

    National Natural Science Foundation of China, 81170640, 30960385

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摘要：

虽然肾脏移植术为肾功能不全晚期患者提供了一种有效的治疗策略，但尚存在供体器官有限、免疫排斥反应和终身服用免疫抑制剂等缺陷。多能干细胞具有无限自我增殖能力及在体内分化成为多种类型细胞的特点，尤其是胚胎干细胞和诱导性多能干细胞可分化为人体内的任何一种细胞，在组织、器官再生方面显示出良好的应用前景。该文主要对多能干细胞在肾脏再生方面的研究进展进行综述。

关键词: 多能干细胞, 胚胎干细胞, 诱导性多能干细胞, 肾脏再生, 细胞分化

Abstract:

Although renal transplantation has been proved to be an effective therapeutic strategy for most patients with end-stage renal failure, it is associated with some limitations, including the shortage of donor organs, immune rejection and a lifelong immunosuppressive regimen. Pluripotent stem cells, especially embryonic stem cells and induced pluripotent stem cells, can differentiate into any cell types in the body and show a good prospect of application on tissue and organ regeneration. The research progress of pluripotent stem cells and kidney regeneration is reviewed in this paper.

Key words: pluripotent stem cell, embryonic stem cell, induced pluripotent stem cell, kidney regeneration, cell differentiation