上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2020, Vol. 40 ›› Issue (4): 534-.doi: 10.3969/j.issn.1674-8115.2020.04.020

• 综述 • 上一篇    下一篇

N6- 腺苷酸甲基化RNA修饰在免疫调控中的作用

祝旭颖，林其圣，倪兆慧   

  1. 上海交通大学医学院附属仁济医院肾脏科，上海200127
  • 出版日期:2020-04-28 发布日期:2020-05-22
  • 通讯作者: 倪兆慧，电子信箱：profnizh@126.com。
  • 作者简介:祝旭颖（1992—），女，硕士生；电子信箱：xuyingzh1@163.com。
  • 基金资助:
    国家自然科学基金（81770666，81570604）；上海市卫生和计划生育委员会科研基金（201740037）。

Effect of RNA N6-methyladenosine on immunoregulation

ZHU Xu-ying, LIN Qi-sheng, NI Zhao-hui   

  1. Department of Nephrology, Renji hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2020-04-28 Published:2020-05-22
  • Supported by:
    National Natural Science Foundation of China (81770666, 81570604); Foundation of Shanghai Municipal Commission of Health and Family Planning (201740037).

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摘要： N6-腺苷酸甲基化（N6-methyladenosine，m6A）是真核细胞中最常见、最丰富的信使RNA（message RNA，mRNA）内部修饰，在甲基转移酶和去甲基酶的作用下，形成一种动态、可逆的甲基化过程，参与多种细胞基因表达调控与生物学过程。近年来，研究发现m6A修饰在免疫细胞分化与调控功能中具有重要作用，这为免疫系统相关性疾病的研究和治疗提供了新思路。文章就近年来m6A 修饰在免疫调控中的作用相关研究进展作一综述。

关键词: N6- 腺苷酸甲基化, RNA修饰, 甲基转移酶, 去甲基酶, 免疫

Abstract:

N6-methyladenosine (m6A) is the most prevalent and abundant post-transcriptional RNA modification in eukaryotes. m6A is a dynamic and reversible process catalyzedm6A methyltransferase complex and demethylase. m6A is involved in the regulations of gene and biological processes. Recently, researches have discovered that m6A plays a vital role in the differentiation and regulation of immune cells, which could provide a new idea for the research and therapy of immune-related diseases. The present article reviews the recent progresses of m6A in immunoregulation.

Key words: N6-methyladenosine, RNA modification, methyltransferase, demethylase, immune