上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2015, Vol. 35 ›› Issue (10): 1464-.doi: 10.3969/j.issn.1674-8115.2015.10.007

• 论著（临床研究） • 上一篇    下一篇

海洛因依赖患者戒断后血浆5-羟色胺水平的改变与焦虑、抑郁情绪的关系

张乔阳，张凯，江海峰，杜江，赵敏   

  1. 上海交通大学 医学院附属精神卫生中心， 上海 200030
  • 出版日期:2015-10-20 发布日期:2015-12-22
  • 通讯作者: 赵敏, 电子信箱: drminzhao@gmail.com
  • 作者简介:张乔阳（1989—）， 女， 硕士生; 电子信箱: qiaoyang.zhang@hotmail.com
  • 基金资助:

    国家自然科学基金（81271468）；上海市卫计委联合攻关项目（2014ZYJB0002）

Correlations between the change of plasma serotonin level, anxiety, and depression of heroin addicts after withdrawal

ZHANG Qiao-yang, ZHANG Kai, JIANG Hai-feng, DU Jiang, ZHAO Min   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Natural Science Foundation of China， 81271468； Joint Research Project of Shanghai Municipal Health and Family Planning Commission, 2014ZYJB0002

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摘要：

目的观察海洛因依赖患者戒断后血浆5-羟色胺（5-HT）水平及焦虑、抑郁情绪的变化，探索其戒断后焦虑、抑郁情绪与5-HT的关系。方法从强制隔离戒毒所招募53例海洛因依赖患者，进行为期26周的海洛因戒断，戒断前后采用焦虑自评量表（SAS）、抑郁自评量表（SDS）评估其焦虑、抑郁状况，检测血浆5-HT、5-羟吲哚乙酸（5-HIAA）的质量浓度，并计算5-HT转化率。结果戒断26周后，海洛因依赖患者SAS得分明显下降（t=2.196, P<0.05），SDS得分无明显改变（t=1.127, P>0.05）。海洛因依赖患者血浆5-HT、5-HIAA水平均明显上升（t=-7.083, P<0.001；t=-4.316, P<0.001），5-HT转化率明显下降（t=4.026, P<0.001）。5-HT与SAS得分在基线及戒断26周时呈负相关（r=-0.28, P<0.05；r=-0.295, P<0.05），5-HT与SDS得分无相关性（P>0.05）。结论海洛因依赖患者戒断后焦虑情绪的缓解可能与血浆5-HT水平的升高有关。

关键词: 海洛因, 焦虑, 抑郁, 5-羟色胺, 5-羟吲哚乙酸

Abstract:

ObjectiveTo observe the changes of 5-hydroxytryptamine (5-HT) level in the plasma, anxiety, and depression of heroin addicts after withdrawal and explore the correlations between 5-HT, anxiety, and depression after withdrawal.Methods A total of 53 heroin addicts were enrolled from a compulsory rehabilitation center and the withdrawal of heroin lasted for 26 weeks. Anxiety and depression symptoms were assessed by self-rating anxiety scale（SAS）and self-rating depression scale (SDS) before and after withdrawal. Plasma 5-HT and 5-hydroxyindoleacetic acid（5-HIAA）levels were detected and the 5-HT turnover rate was calculated. ResultsThe SAS score of heroin addicts significantly decreased after 26 weeks of withdrawal (t=2.196, P<0.05) and the SDS score did not change remarkably (t=1.127, P>0.05). The plasma 5-HT (t=-7.083, P<0.001) and 5-HIAA (t=-4.316, P<0.001) levels of heroin addicts significantly increased, while the 5-HT turnover rate significantly decreased (t=4.026, P<0.001). The plasma 5-HT levels at baseline (r=-0.28, P<0.05) and after 26 weeks of withdrawal (r=-0.295, P<0.05) negatively correlated with SAS scores at baseline and after 26 weeks of withdrawal. The plasma 5-HT level did not correlate with the SDS score (P>0.05).ConclusionThe relief of anxiety of heroin addicts after withdrawal may be relevant to the increase of plasma 5-HT level.

Key words: heroin, anxiety, depression, 5-hydroxytryptamine, 5-hydroxyindoleacetic acid