Research progress in the role and mechanism of abnormal mitophagy in Alzheimer's disease

doi:10.3969/j.issn.1674-8115.2022.03.019

Abstract

Abstract:

Alzheimer's disease (AD) is a neurodegenerative disease and one of the main types of senile dementia. In recent years, abnormal mitophagy often occurs in AD patients. Relevant studies have shown that mitophagy is an important way to control the quality and quantity of mitochondria, that is, cells can remove damaged or dysfunctional mitochondria through selective autophagy to maintain the normal physiological function and energy supply. This article reviews the abnormal changes of mitophagy in AD and its role and mechanism in the occurrence and development of AD, in order to offer new ideas for controlling and delaying the process of AD by targeted induction of mitophagy.

Key words: Alzheimer's disease (AD), mitophagy, mitochondria

CLC Number:

R749.1⁺6

LIN Yijia, CHENG Lizhen, MIAO Ya. Research progress in the role and mechanism of abnormal mitophagy in Alzheimer's disease[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(3): 387-392.

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References 42

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