JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (12): 1618-1620.doi: 10.3969/j.issn.1674-8115.2020.12.008

• Original article (Clinical research) • Previous Articles     Next Articles

Relationship between serum interleukin-6 level and depressive symptoms in schizophrenia

WEN Wan-jun1, CHEN Ye1, QIN Zong-hou1, LÜ Wang-qiang2, TANG Wei3, LU Wei-hong4, FAN Wei-xing2, ZHANG Chen4   

  1. 1. Department of Psychiatry, Yuebei Third People’s Hospital, Shaoguan, Guangdong Province, Shaoguan 512200, China; 2. Department of Psychiatry, The Second Hospital of Jinhua, Zhejiang Province, Jinhua 321016, China; 3. Department of Psychiatry, The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou 325000, China; 4. Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-12-28 Published:2021-02-02
  • Supported by:
    National Natural Science Foundation of China (81771450).

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Abstract: Objective · To explore the relationship between serum interleukin-6 (IL-6) level and depressive symptoms in schizophrenia. Methods · A total of 239 patients with schizophrenia treated with olanzapine alone for more than 2 years were enrolled. Calgary Depression Scale for Schizophrenia (CDSS) was used to evaluate the depression level of the patients, and they were divided into depression group and non-depression group. Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms of patients. Serum IL-6 levels were measured by enzyme linked immunosorbent assay (ELISA), and the differences between the two groups were compared. Pearson correlation analysis was used to analyze the relationship between serum IL-6 level and CDSS score. Results · According to the results of CDSS, the patients were divided into depression group (119 cases) and non-depression group (120 cases). Compared with the non-depression group, the PANSS negative symptom subscale score and serum IL-6 level of patients in the depression group were higher (P=0.028, P=0.000). Pearson correlation analysis showed that serum IL-6 level was positively correlated with CDSS score in the depression group patients (r=0.42, P=0.000). Conclusion · The increase of serum IL-6 level may be related to the occurrence of schizophrenia with depression symptoms.

Key words: schizophrenia, interleukin-6 (IL-6), depressive symptom, Calgary Depression Scale for Schizophrenia (CDSS)

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