上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (1): 94-.

• 综述 • 上一篇    下一篇

固有免疫在钩端螺旋体感染中作用的研究进展

邓 聪1, 综述；郭晓奎2, 姜叙诚1,  审校   

  1. 上海交通大学 基础医学院 1. 病理学教研室, 2. 病原生物学教研室, 上海 200025
  • 出版日期:2010-01-26 发布日期:2010-01-26
  • 通讯作者: 姜叙诚, 电子信箱: xjiang@shsmu.edu.cn。
  • 作者简介:邓 聪（1986—）, 女, 硕士生；电子信箱: cc_48@163.com。
  • 基金资助:

    国家自然科学基金(30770820)；上海市自然科学基金(06ZR14056)

Research progress of role of innate immunity in infection of leptospira

DENG Cong1, reviewer；GUO Xiao-kui2, JIANG Xu-cheng1 reviser   

  1. 1. Department of Pathology, 2. Department of Microbiology and Parasitology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2010-01-26 Published:2010-01-26
  • Supported by:

    National Natural Science Foundation of China, 30770820；Natural Science Foundation of Shanghai, 06ZR14056

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摘要：

钩端螺旋体病是一种在世界范围内传播的重要的人兽共患病。钩端螺旋体（钩体）感染机体后，固有免疫在早期控制感染扩散中的作用及意义逐渐受到重视。巨噬细胞对钩体具有吞噬和杀伤作用，同时，致病性钩体可逃避巨噬细胞杀伤。中性粒细胞、补体系统和细胞因子在抵御钩体感染方面也具有一定的作用。

关键词: 钩端螺旋体病, 固有免疫, 巨噬细胞

Abstract:

Leptospirosis is an important zoonosis with worldwide distribution. As the first procedure in immunity system, the role and significance of innate immunity in controlling infection at the early stage of the disease have gradually been emphasized. Macrophages can phagocytize and kill leptospira, while the pathogenic leptospira can evade the killing by macrophages. In addition, neutrophils, complement system and cytokines also contribute to the defence of leptospira infection.

Key words: leptospirosis, innate immunity, macrophage