上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (3): 353-.

• 综述 • 上一篇    下一篇

纳米粒子靶向治疗乳腺癌研究进展

马 杰, 综述；房 林, 审校   

  1. 同济大学附属第十人民医院普外科, 上海 200072
  • 出版日期:2010-03-25 发布日期:2010-03-24
  • 作者简介:马 杰（1983—）, 男, 硕士生；电子信箱: altmajie@126.com。

Research progress of nanoparticles-targeted therapy for breast cancer

MA Jie, reviewer；FANG Lin, reviser   

  1. Department of General Surgery, The Tenth People's Hospital, |Tongji University, Shanghai 200072, China
  • Online:2010-03-25 Published:2010-03-24

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摘要：

纳米粒子为抗肿瘤药物的转运提供了一种新方法，它可以作为肿瘤药物的载体，穿透肿瘤组织中血管内皮间隙并直接进入细胞发挥作用。这些微粒通过修饰后，能与肿瘤组织中的内环境、细胞膜、细胞质或细胞核上的靶点特异结合，并作用于肿瘤细胞，在不损伤正常细胞的情况下，使高浓度的药物靶向肿瘤细胞，从而达到治疗肿瘤的目的。文章就纳米粒子的作用机制及其在乳腺癌治疗中的应用研究作一综述。

关键词: 纳米粒子, 乳腺癌, 药物转运

Abstract:

Nanoparticles provide a new approach for antitumor drug delivery as a carrier for penetrating tumor vasculature and entering into tumor cells. After modification for nanoparticles, these particles target to tumor cell membranes, tumor microenvironment, cytoplasmic or nuclear receptors. Nanoparticles deliver high concentration of drug to the targeted tumor cells, with reduced toxicity to normal tissues. In this article, the mechanisms and latest researches on the application of nanoparticles in the treatment of breast cancer are reviewed.

Key words: nanoparticles, breast cancer, drug delivery