上海交通大学学报（医学版）

上海交通大学学报（医学版）

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自噬与肿瘤耐药关系的研究进展

许红玲，张萍   

  1. 上海交通大学 医学院附属新华医院妇产科， 上海 200092
  • 出版日期:2016-06-28 发布日期:2016-07-25
  • 作者简介:许红玲（1990—）， 女， 硕士生; 电子信箱: 727745108@qq.com。

Research progresses of relationship between autophagy and drug resistance of tumor

XU Hong-ling， ZHANG Ping   

  1. Department of Gynaecology， Xinhua Hospital， Shanghai Jiao Tong University School of Medicine, Shanghai 200092， China
  • Online:2016-06-28 Published:2016-07-25

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摘要：

自噬是一种极其保守的细胞代谢过程，主要是细胞中的细胞器以及蛋白质被包裹在自噬体中，并运送到溶酶体中降解的过程。近年来，肿瘤与自噬的关系一直颇受关注。大量研究表明，多种化疗药物能够诱导肿瘤细胞自噬的发生，而且对肿瘤细胞自噬的抑制可导致不同的结局——生存或者死亡。自噬是肿瘤治疗一个潜在的重要途径,但由于自噬在肿瘤形成和发展中的作用目前仍存在争议，通过调控自噬过程提高肿瘤治疗效果，尚待更多的研究。

关键词: 自噬, 肿瘤治疗, 耐药

Abstract:

Autophagy is a highly conservative process of cell metabolism, which mainly involves the process that proteins and organelles in cells are wrapped in autophagies and transported to lysosomes for degradation. In recent years, the relationship between autophagy and tumor has become a research focus. A large number of studies have shown that a variety of chemotherapy drugs can induce the occurrence of tumor cell autophagy and the inhibition of tumor cell autophagy can lead to different outcomes: survival or death. Autophagy is an important potential approach to tumor treatment. But more studies are needed to improve the efficacy of tumor treatment via regulation of the autophagy process due to the roles of autophagy in tumor formation and development are still controversial.

Key words: autophagy, tumor therapy, drug resistance