复发性流产中胎盘细胞铁死亡的研究进展

doi:10.3969/j.issn.1674-8115.2025.10.014

上海交通大学学报（医学版） ›› 2025, Vol. 45 ›› Issue (10): 1383-1389.doi: 10.3969/j.issn.1674-8115.2025.10.014

复发性流产中胎盘细胞铁死亡的研究进展

李广慧¹, 冯晓玲²()

^1.黑龙江中医药大学研究生院，哈尔滨 150040
^2.黑龙江中医药大学附属第一医院妇科二科，哈尔滨 150040

收稿日期:2025-05-05 接受日期:2025-09-19 出版日期:2025-10-28 发布日期:2025-10-20
通讯作者: 冯晓玲，教授，博士；电子信箱：doctorfengmen@163.com。
基金资助:
国家自然科学基金(82174421,82205163);中医药循证能力提升项目(国中医药科技中药便函[2023]24号);黑龙江省自然科学基金(SC2022ZX06C0002)

Research progress on ferroptosis of placental cells in recurrent spontaneous abortion

LI Guanghui¹, FENG Xiaoling²()

^1.Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China
^2.Gynecology Department II, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China

Received:2025-05-05 Accepted:2025-09-19 Online:2025-10-28 Published:2025-10-20
Contact: FENG Xiaoling, E-mail: doctorfengmen@163.com.
Supported by:
National Natural Science Foundation of China(82174421,82205163);Natural Science Foundation of Heilongjiang Province(SC2022ZX06C0002);Chinese Medicine Evidence-Based Capacity Enhancement Program (Letter No. [2023] 24 of the State Science and Technology of Traditional Chinese Medicine)

摘要/Abstract

摘要：

复发性流产（recurrent spontaneous abortion，RSA）是一种病因复杂的妊娠并发症，严重威胁育龄期女性的生育和身心健康。胎盘作为母胎界面的主要组成部分，在妊娠期间对孕产妇和胎儿健康起着核心作用，其功能障碍与RSA的发生密切相关。铁稳态是支持母体需求、胎盘功能和胎儿发育所必需的。近年来，铁死亡作为铁过载和脂质过氧化物积累引发的新型细胞死亡形式，在女性生殖系统生理和病理过程中的调控机制受到越来越多的关注，已被证实与胎盘病理状态相关并影响RSA的发病。胎盘在调节铁运输方面发挥着关键作用。该文综述了胎盘细胞铁死亡的发生机制及其通过影响滋养层细胞功能、引起蜕膜化缺陷和抑制血管生成参与RSA发病的作用机制，分析铁死亡相关分子在RSA治疗上的潜在可能，以期为改善RSA患者的妊娠结局提供研究方向。

关键词: 复发性流产, 胎盘, 铁死亡, 滋养层细胞, 蜕膜化, 血管生成

Abstract:

Recurrent spontaneous abortion (RSA) is a pregnancy complication with a complex etiology that seriously threatens the fertility and physical and mental health of women of childbearing age. As the main component of the maternal-fetal interface, the placenta plays a central role in maternal and fetal health during pregnancy, and its dysfunction is closely associated with the development of RSA. Iron homeostasis is essential for supporting maternal needs, placental function, and fetal development. In recent years, ferroptosis, a novel form of cell death triggered by iron overload and the accumulation of lipid peroxides, has garnered increasing attention regarding its regulatory mechanisms in the physiological and pathological processes of the female reproductive system. Ferroptosis has been confirmed to correlate with placental pathology and to influence the pathogenesis of RSA. The placenta plays a crucial role in regulating iron transport. This paper systematically reviewed the mechanisms of ferroptosis in placental cells and its involvement in the pathogenesis of RSA by affecting trophoblast cell function, causing decidualization disorders, inducing angiogenesis defects, and the potential of ferroptosis-related molecules in the treatment of RSA was analyzed, with the aim of providing research directions for improving the pregnancy outcomes in patients with RSA.

Key words: recurrent spontaneous abortion, placenta, ferroptosis, trophoblast cell, decidualization, angiogenesis

中图分类号:

R714.21

李广慧, 冯晓玲. 复发性流产中胎盘细胞铁死亡的研究进展[J]. 上海交通大学学报（医学版）, 2025, 45(10): 1383-1389.

LI Guanghui, FENG Xiaoling. Research progress on ferroptosis of placental cells in recurrent spontaneous abortion[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(10): 1383-1389.

图/表 1

参考文献 48

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复发性流产中胎盘细胞铁死亡的研究进展

Research progress on ferroptosis of placental cells in recurrent spontaneous abortion

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