JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (8): 1094-1098.doi: 10.3969/j.issn.1674-8115.2021.08.016

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Research progress in epigenetics in methamphetamine use and addiction

Ying-jie CHENG(), Qian-qian SUN, Min ZHAO()   

  1. Department of Substance Dependence and Addiction, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2021-08-28 Published:2021-08-13
  • Contact: Min ZHAO;
  • Supported by:
    National Nature Science Foundation of China(81771436);Project of Shanghai Municipal Health and Family Planning Commission(2017ZZ02021)


Methamphetamine is a central nerve psychostimulant with strong addictive effects and neurotoxicity. However, the mechanism of methamphetamine addiction is still unknown. Epigenetics regulates gene expression without influencing DNA sequence and is a research hotspot in recent years. Increasing researches indicate that epigenetics may participate in methamphetamine-induced brain structure and function alterations. This may provide new insights for exploring the pathogenesis of methamphetamine addiction. This article reviews the advances of epigenetic researches related to methamphetamine use and addiction.

Key words: methamphetamine (METH), addiction, histone modification, DNA methylation, non-coding RNA

CLC Number: