›› 2010, Vol. 30 ›› Issue (11): 1424-.doi: 10.3969/j.issn.1674-8115.2010.11.026

• Review • Previous Articles     Next Articles

Research progress of relationship between clozapine and metabolic syndrome

CHEN Jian-hua1,2, LIU Deng-tang2, LI Yan2, XU Yi-feng2   

  1. 1.Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai 200021, China;2.Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2010-11-25 Published:2010-11-29


Metabolic syndrome, including diabetes, increased fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure, is a cluster of risk factors for cardiovascular diseases. Clozapine is one of the atypical antipsychotics which have negative effects on body weight, plasma lipid concentration and plasma glucose control, and may increase the risks of suffering from metabolic syndrome. The relationship between clozapine and metabolic syndrome is reviewed in this paper.

Key words: antipsychotics, schizophrenia, metabolic syndrome