›› 2015, Vol. 35 ›› Issue (10): 1491-.doi: 10.3969/j.issn.1674-8115.2015.10.012

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Study on the correlation between INSIG2 and metabolic syndrome

YANG Lin1,2, CHEN Jian-hua1, WANG Zhen1, YANG Wei-min1, SHI Shen-xun2, XU Yi-feng1,2   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, China; 2.Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai200021, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Natural Science Foundation of China, 81171271； Shanghai Key Laboratory of Psychotic Disorders, 13dz2260500； the Research Project of Shanghai Municipal Health and Family Planning Commission， 201440552

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Abstract:

ObjectiveTo investigate the correlation between the polymorphism of insulin induced gene 2 (INSIG2) and metabolic syndrome (MetS) relevant to administration of clozapine for Han Chinese patients with schizophrenia.MethodsMedical histories and clinical data of 621 schizophrenia patients treated with clozapine for at least one year were enrolled and metabolic indexes were measured. Eight single nucleotide polymorphisms (SNPs) of INSIG2 were genotyped. All data was grouped according to the criteria of metabolic syndrome and statistically analyzed by SPSS 17.0 and SHEsis. ResultsThe incidence of MetS of 621 schizophrenia patients treated with clozapine was 41.8%. The allelic and genotypic frequencies of locus rs17587100 of INSIG2 between two groups were different after relevant clinical data was adjusted (P<0.05). However, the differences were not statistically significant after False Discovery Rate (FDR) correction of multiple hypothesis testing (P>0.05). ConclusionThe polymorphism of INSIG2 doesn’t correlate with MetS relevant to administration of clozapine.

Key words: schizophrenia, metabolic syndrome, clozapine, INSIG2