上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2013, Vol. 33 ›› Issue (6): 868-.doi: 10.3969/j.issn.1674-8115.2013.06.034

• 综述 • 上一篇    下一篇

外泌体及其在干细胞中的研究进展

胡国文1，汪 泱2，沈晓黎1，邓志锋1,3   

  1. 1.南昌大学 第二附属医院神经外科, 南昌 330006； 2.上海交通大学附属第六人民医院四肢显微外科研究所， 上海 200233； 3.上海交通大学附属第六人民医院神经外科， 上海 200233
  • 出版日期:2013-06-28 发布日期:2013-06-28
  • 作者简介:胡国文（1991—）， 男， 硕士生; 电子信箱: hugw0625@163.com。
  • 基金资助:

    国家自然科学基金（81170640，81272170）

Research progress of exosomes in stem cells

HU Guo-wen1, WANG Yang2, SHEN Xiao-li1, DENG Zhi-feng1,3   

  1. 1.Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China, 2.Institute for Microsurgery of Extremities, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China; 3.Department of Neurosurgery, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2013-06-28 Published:2013-06-28
  • Supported by:

    National Natural Science Foundation of China，81170640，81272170

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摘要：

外泌体是在细胞间交流中起重要作用的小分泌囊泡，可由多种类型的细胞分泌，在细胞间起着质膜交换及转运蛋白质、mRNA、microRNA和细胞器等生命活性物质的作用。外泌体可通过改变基因调控网络或表观遗传重组来调控正常的生理过程。最近的研究发现，干细胞分泌的外泌体可以有效转运mRNA、microRNA和蛋白质，在调控组织再生方面发挥重要作用。该文对外泌体的生成及其在干细胞中的研究进展进行综述。

关键词: 外泌体, 干细胞, 再生医学

Abstract:

Exosomes are small secreted vesicles, which play key roles in cell-to-cell communication. Exosomes can be released by different types of cells, and help to exchange membrane and transfer proteins, mRNA, microRNA and organelles between cells. Exosomes modulate normal physiological processes by transforming gene regulatory network or epigenetic reorganization. Recent studies have found that exosomes secreted by stem cells can transport mRNA, microRNA and proteins effectively, and play an important role in regulating tissue regeneration. The generation of exosomes and the research progress of exosomes in stem cells are reviewed in this paper.

Key words: exosome, stem cells, regenerative medicine