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    Research progress of effect of carotenoids on maternal and child health
    WU Ke1, SUN Han-xiao2, CAI Mei-qin1
       2019, 39 (8): 929-.   DOI: 10.3969/j.issn.1674-8115.2019.08.021
    Abstract409)      PDF(pc) (7354KB)(1987)       Save
    Early life nutrition plays an important role in determining the pregnancy outcomes and offspring lifelong health. Carotenoids deficiency is associated with adverse pregnancy outcomes such as preeclampsia, premature delivery and intrauterine growth restriction. Carotenoids possess antioxidant, inflammation modulating and immune-enhancing properties and promote visual, cognitive and respiratory health in offsprings. Among carotenoids, α-carotene, β-carotene and β-cryptoxanthin can be transformed into vitamin A in vivo, and their conversion rates are affectedthe nutritional status of vitamin A. Lutein and zeaxanthin are highly enriched in the brain and retina of infants and young children, which are closely related to the development of visual acuity and cognitive function. Breast milk contains an adequate level of lutein and its absorption rate is significantly higher than that of infant formulas. Consequently lutein supplementation is necessary for artificially fed infants, especially premature infants. In this paper, the functional research progresses of carotenoids related to adverse pregnancy outcomes and offspring development, as well as the present situation of carotenoids supplementation in formula were reviewed.
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       2019, 39 (6): 2-.  
    Abstract380)      PDF(pc) (8346KB)(715)       Save
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       2019, 39 (12): 2-.  
    Abstract144)      PDF(pc) (947KB)(621)       Save
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    Relationship between aggressive behavior in patients with bipolar disorder and DRD4 gene polymorphism and personality characteristics
    YANG Dao-liang, LIU Han, WU Yu-jie, DU Wen-yong, JI Wei-dong, CHEN Xuan-xuan
       2020, 40 (3): 362-.   DOI: 10.3969/j.issn.1674-8115.2020.03.014
    Abstract491)      PDF(pc) (7776KB)(496)       Save
    Objective · To explore the relationship between aggressive behavior, dopamine receptor D4 (DRD4) exon Ⅲ 48 bp variable number tandem repeat (VNTR) and personality characteristics in patients with bipolar disorder. Methods · January 2015 to December 2018, 173 patients with bipolar disorder were selected Shanghai Changning Mental Health Center, Shanghai Jingan Mental Health Center, Shanghai Xuhui Mental Health Center, and Shanghai Jiading Central Hospital. According to the score of Modified Overt Aggression scale (MOAS), 173 patients were divided into aggressive behavior group (research group) and non-aggressive behavior group (control group). General survey and the temperament and personality questionnaire (Temperature and Character Inventory, TCI) were carried out, respectively. The polymorphism of DRD4 gene were genotypedthe polymerase chain reaction-restriction fragment length polymorphism method. Genetic equilibrium test of genotype Hardy-Weinberg and the difference of genotype frequency between the two groups were analyzedusing SHEsis software. The relationship between aggression behavior and DRD4 gene polymorphism and personality traits in bipolar disorder patients was analyzedχ2 test and t test. Results · There was no significant difference in the general data between research group and control group (P>0.05). Six alleles and nine genotypes of DRD4 exon Ⅲ 48 bp VNTR were detected. The most common alleles in the two groups were four repeat alleles. There were statistical differences in the frequency distribution of genotypes and alleles of DRD4 exon Ⅲ 48 bp VNTR between the two groups (P0.040, P0.018). The scores of novelty seeking and harm avoidance in the research group were higher than those in the control group (P0.026, P0.000), while the scores of cooperativeness and self-directedness were lower than those in the control group (both P0.000). Patients with long repeat alleles had significantly higher scores in novelty seeking and harm avoidance, and lower scores in cooperativeness, compared with patients with short repeat alleles (P0.000, P0.006, P0.038). Conclusion · Aggressive behavior in patients with bipolar disorder may be associated with DRD4 exon Ⅲ 48 bp VNTR. In bipolar disorder, patients with aggressive behavior have unique personality characteristics in impulsiving, novelty-seeking, exploring, being afraid of uncertainty, revengeful, behaving himself and so on. Patients with long repeat alleles have more significant personality abnormalities.
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    Tactile imaging and its application to pelvic floor dysfunction
    QIU Yu, WU Qing-kai, HUANG Cheng-sheng
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)   
    Online available: 21 May 2020

       2019, 39 (7): 3-.  
    Abstract297)      PDF(pc) (1818KB)(480)       Save
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    Association study of synaptotagmin 2 gene polymorphisms with schizophrenia in Chinese Han population
    Hong YANG, Xin-xin HUANG, Chao LIU, Qing-song LIANG, Hua YANG, Jian-biao ZHANG, Jian XU, Ying-yi WANG, Hai-su WU, Qin-yu LÜ, Zheng-hui YI
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2021, 41 (1): 16-22.   DOI: 10.3969/j.issn.1674-8115.2021.01.003
    Abstract246)   HTML2)    PDF(pc) (1352KB)(469)       Save
    Objective

    ·To investigate the relationship between synaptotagmin 2 (SYT2) gene and schizophrenia (SZ) in Chinese Han population.

    Methods

    ·TaqMan probe genotyping technique was used to detect 5 single nucleotide polymorphism (SNP) sites (rs6427957,rs907697,rs12564274,rs10800856 and rs61820945) of SYT2 gene in 478 SZ patients (SZ group) and 474 healthy controls (HC group). HaploView software, SHEsis and SNPstats online software were used to compare the alleles, genotypes, genotypes under different genetic models and haplotypes frequency distribution between the SZ group and HC group.

    Results

    ·The frequency distribution differences of rs10800856 allele and genotype were statistically significant between the SZ group and HC group, respectively (P=0.003, P=0.012). After Bonferroni correction, the allele frequency difference of rs10800856 site was still statistically significant (P=0.015), while the genotype frequency difference was not statistically significant. Under the dominant and additive genetic mode, the genotype frequency distributions of rs10800856 site were significantly different between the SZ group and HC group (P=0.004, P=0.005). After correction, the differences were still statistically significant (P=0.020, P=0.025). The frequency distribution of haplotype C-T-C, composed of rs12564274-rs10800856-rs61820945, between the SZ group and HC group was significantly different (P=0.009). After Bonferroni correction, the difference was still statistically significant (P=0.036).

    Conclusion

    ·In Chinese Han population, SYT2 may be the susceptibility gene of SZ, and rs10800856 site may be associated with the risk of SZ.

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       2019, 39 (6): 3-.  
    Abstract425)      PDF(pc) (2292KB)(456)       Save
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    Advances in anesthesia research of modified electroconvulsive therapy
    JIA Yu-ping, JIANG Jiang-ling, XIAO Wen-bin, LI Chun-bo
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)   
    Online available: 27 May 2020

       2020, 40 (3): 2-.  
    Abstract269)      PDF(pc) (10722KB)(430)       Save
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    Application of artificial intelligence in assisted diagnosis and treatment of cardiovascular disease
    LU Yan-qiao, SHEN Lan, HE Ben
       2020, 40 (2): 259-.   DOI: 10.3969/j.issn.1674-8115.2020.02.019
    Abstract579)      PDF(pc) (6215KB)(413)       Save
    With the continuous development of science and technology, artificial intelligence (AI) with self-directed learning, induction and deduction, low error rate and other advantages has become the most popular emerging technology. In the traditional medical field, especially in cardiovascular diseases with high incidence, AI can not only provide auxiliary diagnosis and treatment for patients, but also enable doctors to optimize traditional risk assessment models which can predict the evolution of the disease better. Thereby, AI can provide more convenience and new perspectives for clinical work. This paper reviews the research progress of AI in the cardiovascular field in recent years.
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    Research progresses in transcutaneous vagus nerve stimulation
    GU Nan-nan, LI Chun-bo
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)   
    Online available: 29 March 2020

    Palmitoylation of PD-L1 is a new target for cancer immunotherapy
    The research group of XU Jie
       2019, 39 (7): 689-.   DOI: 10.3969/j.issn.1674-8115.2019.07.001
    Abstract806)      PDF(pc) (3490KB)(403)       Save
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    A novel antithrombotic antibody targeting the binding sites of the coagulation factor FⅨa-FⅧa complex
    Tian-yao SUN, Shi-feng JIANG, Qin XU, Jun-ling LIU, Su-ying DANG, Xue-mei FAN
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2021, 41 (9): 1133-1141.   DOI: 10.3969/j.issn.1674-8115.2021.09.001
    Abstract133)      PDF(pc) (6502KB)(383)       Save
    Objective

    ·To prepare a monoclonal antibody targeting coagulation factor Ⅸa (FⅨa), a key factor in endogenous coagulation pathways, and study its antithrombotic roles and mechanisms.

    Methods

    ·Immunization of mice, hybridoma technology, cell expression and purification were used to prepare the anti-FⅨa monoclonal antibodies of high purity. The monoclonal antibodies with high affinity for FⅨa were screened by enzyme-linked immunosorbent assay. The activated partial thromboplastin time (APTT) and prothrombin time (PT) were used to evaluate the antithrombotic effects of the monoclonal antibody. And then chromogenic substrate method was used to detect the effect of monoclonal antibody on the enzyme activity of FⅨa. The method of computer simulation of protein-protein docking was adopted to predict the possible binding sites between FⅨa and the antibody, and the binding site, was verified by competitive experiments (indirectly through the chromatic substrate method).

    Results

    ·FⅨa-4, an anti-FⅨa monoclonal antibody with high affinity, was generated. Although FⅨa-4 did not affect PT and the enzyme activity of FⅨa, it significantly prolonged APTT to 88.8 s, which was 3.5 times of the control group (25.5 s), in a concentration-gradient dependence. The protein-protein docking prediction results revealed that FⅨa-4 did not directly bind to substrate catalytic sites of FⅨa, but occupied the binding region of FⅨa and FⅧa. Competitive experiments further verified the above results. FⅨa-4 inhibited FⅩa production in a dose-dependent manner, almost completely inhibiting FⅩa production at the concentrations of 400 pmol/L, and FⅧa could correct the inhibition effect of the antibody up to nearly 50%.

    Conclusion

    ·The monoclonal antibody against FⅨa-4 is obtained. FⅨa-4 competes with FⅧa to bind FⅨa, and inhibits the conversion of FⅩ to FⅩa which is catalyzed by FⅧa-FⅨa complex; it plays an antithrombotic role mainly by inhibiting endogenous coagulation pathway.

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    Role and mechanism of PRMT4 in genesis and progression of gastric cancer
    DOU Min, ZHENG Ying-xia, HAN Li, ZHAO Qian
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)   
    Online available: 25 April 2020

    Application of optical coherence tomography angiography to evaluation of clinical effect of anti- vascular endothelial growth factor agents on wet age-related macular degeneration
    ZHANG Qiong, LIN Zhong-jing, ZHANG Shi-sheng, HU Qi-wei, SHEN Xi, XU Jian-min
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)   
    Online available: 31 July 2020

    Expression and clinical significance of α1-antitrypsin in thyroid-associated ophthalmopathy
    WU Yu, LU Yi, SUN Rou, ZHANG Shuo, SUN Jing, ZHOU Hui-fang, FAN Xian-qun
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)   
    Online available: 25 April 2020

       2020, 40 (3): 3-.  
    Abstract331)      PDF(pc) (3260KB)(360)       Save
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    Spatial-temporal distribution of coronavirus disease 2019 in Jingzhou City
    LIN Mao-wen*, LIU Tian*, TIAN Ke-qing, JIANG Hong, ZENG Min-min, WANG Li, YIN Jun, LEI Ruo-qian, YAO Meng-lei, HUANG Ji-gui
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)    2020, 40 (05): 566-572.   DOI: 10.3969/j.issn.1674-8115.2020.05.002
    Abstract503)      PDF(pc) (7202KB)(356)       Save
    Objective · To explore the spatial distribution and spatial-temporal clustering of coronavirus disease 2019 (COVID-19) in Jingzhou City. Methods · Data of COVID-19 cases in Jingzhou City from January 1 to March 12, 2020 were collected. Trend surface analysis, spatial autocorrelation and spatial-temporal scanning analysis were conducted to understand the spatial-temporal distribution of COVID-19 at town (street) level in Jingzhou City, and the spatial-temporal clustering characteristics of local cases and imported cases were compared. Results · Trend surface analysis showed that the incidence rate of COVID-19 in Jingzhou City was slightly “U” from west to east, slightly higher in the east, and inverted “U” from south to north, slightly higher in the south. Global autocorrelation showed that the incidence rate of COVID-19 in Jingzhou City was positively correlated (Moran's I=0.410, P=0.000). Local spatial autocorrelation analysis showed that the highly clustered areas and hot spot areas were mainly in Shashi District, Jingzhou District and the main urban area of Honghu City (Xindi Street) (P<0.05). Five clusters were found by spatial-temporal scanning of imported cases. The cluster time of the main cluster was from January 18 to February 3, 2020, and it was centered on Lianhe Street, covering 15 towns (streets) in Shashi District and Jingzhou District (LLR=174.944, RR=7.395, P=0.000). Five clusters were found by spatial-temporal scanning of local cases. The cluster time of the main cluster was from January 20 to February 24, 2020, which was located in Xindi Street, Honghu City (LLR=224.434, RR=16.133, P=0.000). Conclusion · Obvious spatial-temporal clustering of COVID-19 was found in Jingzhou City, and Shashi District, Jingzhou District and Honghu City were the most prevalent areas.
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    Obesity and related metabolic indicators among 270 vegetarians in Shanghai
    QU Lei, CUI Xue-ying, XIE Lu-yao, WANG Bian, TANG Qing-ya, SHEN Xiu-hua
    JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE)   
    Online available: 25 April 2020